Sökning: "interferon"

Visar resultat 1 - 5 av 368 avhandlingar innehållade ordet interferon.

  1. 1. Functional and molecular aspects of interferon action in human natural killer cells and other leucocytes

    Författare :Åke Gustafsson; Erik Lundgren; Umeå universitet; []
    Nyckelord :natural killer cell; large granular lymphocyte; interferon; interferon production; interferon-induced; protein synthesis; two-dimensional electrophoresis;

    Sammanfattning : Interferons comprise a class of structurally related proteins which exert several regulatory effects in responsive cells. These effects include the establishment of an antiviral state, the inhibition of cellular proliferation and the alteration of different immune reactions. LÄS MER

  2. 2. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Författare :Jesper Waldenström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

    Sammanfattning : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. LÄS MER

  3. 3. Studies on the antiproliferative action of interferon : effects on proteins synthesized in the G1 and S phase of the cell cycle in 2 anchorage-dependent cell lines

    Författare :Dan Lundblad; Erik Lundgren; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon; Glioma; Antiproliferative effect; DNA polymerase; Thymidine kinase; 2 -5 oligo A; Protein synthesis; Two-dimensional electrophorensis; Mouse fibroblasts; C-myc; KI-67 antigen;

    Sammanfattning : Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several other inducing agents have been described. LÄS MER

  4. 4. Aspects of interferon alpha signalling in hematopoetic cells

    Författare :Lennart Carlsson; erik lundgren; Ulrich Kalinke; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; interferon; human; B-lymphocyte; survival; proliferation; myeloma; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The type I interferons (IFN) are a family of cytokines with pleiothropic activities that include inhibition of viral replication, cell proliferation and activation of the immune system. These properties give the IFNs important physiological and pathological roles in infection and cancer and have led to their therapeutic use for many clinical conditions. LÄS MER

  5. 5. Monoclonal antibodies to human interferon-α and interferon-γ : Characterization and application with focus on interferon-γ as a T cell cytokine

    Författare :Gudrun Andersson; Stockholms universitet; []

    Sammanfattning : The major functions of the immune system are to combat infections and to control that normal auto-immunity does not turn into auto-aggression. Antibodies, together with T cell receptors and MHC molecules, dictates the immunological specificity. LÄS MER