Sökning: "mRNA modifications"

Visar resultat 6 - 10 av 60 avhandlingar innehållade orden mRNA modifications.

  1. 6. RNA-mediated gene expression regulation

    Författare :Paula Petronela Groza; Francesca Aguilo; Yuri B. Schwartz; Silvia Remeseiro; Henrik Nielsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; fibrillarin; 2 -O-methylation; translation; alternative splicing; METTL3; m6A; ZFP207; breast cancer; mouse ESCs; molekylärbiologi; Molecular Biology;

    Sammanfattning : The regulation of gene expression is a key mechanism that underlies all biological processes, from embryonic development to the onset and progression of various diseases, including cancer. A growing body of evidence places RNA molecules at the center of critical regulatory steps in gene expression. LÄS MER

  3. 7. Functional characterization of the biological significance of the ZBED6/ZC3H11A locus in placental mammals

    Författare :Shady Younis; Leif Andersson; Ola Hansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; IGF2; ZC3H11A; Muscle development; Transcriptome analysis; CRISPR Cas9; mRNA export; Molekylär genetik; Molecular Genetics; Bioinformatik; Bioinformatics;

    Sammanfattning : The recent advances in molecular and computational biology have made possible the study of complicated transcriptional regulatory networks that control a wide range of biological processes and phenotypic traits. In this thesis, several approaches were combined including next generation sequencing, gene expression profiling, chromatin and RNA immunoprecipitation, bioinformatics and genome editing methods in order to characterize the biological significance of the ZBED6 and ZC3H11A genes. LÄS MER

  4. 8. Targeting RNA by the Antisense Approach and a Close Look at RNA Cleavage Reaction

    Författare :Jharna Barman; Lars Baltzer; Roger Strömberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; mRNA targeting; antisense oligonucleotides; target affinity; RNase H; Michaelis-Menten kinetics; exo-nuclease stability; NMR; pH titration; alkaline hydrolysis; Organisk kemi;

    Sammanfattning : This thesis summarizes the results of studies on two aspects of nucleic acids. Chemically modified antisense oligonucleotides (AONs) have been evaluated with regards to their suitability for mRNA targeting in an antisense approach (Paper I – III). LÄS MER

  5. 9. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Författare :Santhilal Subhash; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Sammanfattning : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. LÄS MER

  7. 10. Post-translational modifications in mammary gland development and mammary tumor progression

    Författare :Ting Zhuang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer is one of the most common cancers in women. Estrogen receptor α (ERα) signaling and p53 signaling have important roles in breast cancer progression. Therefore, post-translational modifications of ERα and p53 play critical roles in breast cancer. LÄS MER