Sökning: "Chromatin remodelers"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Chromatin remodelers.

  1. 1. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Författare :Santhilal Subhash; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Sammanfattning : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. LÄS MER

  3. 2. Chromatin remodelers and their roles in chromatin organization

    Författare :Annelie Strålfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein octamer. LÄS MER

  4. 3. Molecular mechanisms underlying the activation of ALC1 nucleosome remodeling

    Författare :Luka Bacic; Sebastian Deindl; Stefan D. Knight; Lari Lehtiö; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; nucleosome; ADP-ribosylation; chromatin; remodeling; PARP1; HPF1; DNA damage; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Packaging DNA into chromatin represses essential DNA-based processes, such as transcription, DNA replication, and repair. To change the accessibility of DNA, cells have evolved a set of enzymes referred to as chromatin remodelers that act on the basic repeat unit of chromatin,  the nucleosome. LÄS MER

  5. 4. Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization

    Författare :Babett Steglich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence accessibility of DNA elements. LÄS MER

  7. 5. Guardians of the genome : Connecting chromatin structure and genome integrity in Saccharomyces cerevisiae

    Författare :Stefanie Lena Bauer; Stefan U. Åström; Brian Luke; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Branched DNA structures arise during recombination and during other DNA repair processes such as repair of stalled replication forks. One branched structure, the Holliday Junction (HJ), is a four-way junction that can connect sister chromatids or homologous chromosomes. We show a physical interaction between the HJ-cleaving enzyme Yen1 and Uls1. LÄS MER