Sökning: "exo-nuclease stability"

Hittade 1 avhandling innehållade orden exo-nuclease stability.

  1. 1. Targeting RNA by the Antisense Approach and a Close Look at RNA Cleavage Reaction

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jharna Barman; Uppsala universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; mRNA targeting; antisense oligonucleotides; target affinity; RNase H; Michaelis-Menten kinetics; exo-nuclease stability; NMR; pH titration; alkaline hydrolysis; Organisk kemi;

    Sammanfattning : This thesis summarizes the results of studies on two aspects of nucleic acids. Chemically modified antisense oligonucleotides (AONs) have been evaluated with regards to their suitability for mRNA targeting in an antisense approach (Paper I – III). LÄS MER