Sökning: "mRNA modifications"
Visar resultat 21 - 25 av 60 avhandlingar innehållade orden mRNA modifications.
21. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
Sammanfattning : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. LÄS MER
22. Cancer proteogenomics : connecting genotype to molecular phenotype
Sammanfattning : The central dogma of molecular biology describes the one-way road from DNA to RNA and finally to protein. Yet, how this flow of information encoded in DNA as genes (genotype) is regulated in order to produce the observable traits of an individual (phenotype) remains unanswered. Recent advances in high-throughput data, i.e. LÄS MER
23. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics
Sammanfattning : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. LÄS MER
24. Bis-locked nucleic acids : a new tool for double helix invasion
Sammanfattning : Deoxyribonucleic acid (DNA) is a macromolecule that contains the information for all living organisms to achieve important cellular processes such as growth and replication. DNA consists of two strands coiled around each other to form a double helix. LÄS MER
25. An RNA story, from chromatin to protein
Sammanfattning : RNA functions expand well over just coding for protein effectors. Non-coding RNAs oversee translation, RNA processing, and spatial organization of the cellular space, therefore participating in the regulation of almost any cellular process. To add a further layer of complexity, both coding and non-coding RNAs are extensively modified. LÄS MER