Sökning: "drug synergy"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden drug synergy.
1. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE
Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER
2. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach
Sammanfattning : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. LÄS MER
3. Strategies to overcome drug resistance in FLT3+ AML
Sammanfattning : Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor survivalrate and limited therapeutic options. Targeted treatment of other types ofcancer, for instance chronic myeloid leukemia (CML) and breast cancer, has seensignificant progress. LÄS MER
4. Optimal design for dose-finding studies
Sammanfattning : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. LÄS MER
5. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia
Sammanfattning : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. LÄS MER