Sökning: "immature rats"

Visar resultat 16 - 20 av 47 avhandlingar innehållade orden immature rats.

  1. 16. Presynaptic mechanisms in L-DOPA-induced dyskinesia

    Författare :Hanna Lindgren; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; dyskinesia; 5-HT; DA; Parkinson s disease; 6-OHDA; microdialysis;

    Sammanfattning : This study has investigated the impact of presynaptic factors on the development of dyskinesia during chronic L-DOPA treatment in a rat model of Parkinson’s disease (PD). The mechanisms causing dyskinesia are not completely understood but have been proposed to involve changes in gene and protein expression in striatal neurons, which are the main target of dopamine (DA) projections from the substantia nigra pars compacta (SNpc). LÄS MER

  3. 17. Ovarian steroids in rat and human brain : effects of different endocrine states

    Författare :Marie Bixo; Bengt Winblad; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Progesterone; 5a-pregnane-3.20-dione; estradiol; testosterone; rat brain; human brain; PMSG-model; steroid anaesthesia;

    Sammanfattning : Ovarian steroid hormones are known to produce several different effects in the brain. In addition to their role in gonadotropin release, ovulation and sexual behaviour they also seem to affect mood and emotions, as shown in women with the premenstrual tension syndrome. Some steroids have the ability to affect brain excitability. LÄS MER

  4. 18. Antimicrobial and xenobiotic defence in the mammalian testis

    Författare :Mona-Lisa Strand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Different mechanisms exist in the mammalian testis to protect the germ cells from autoimmune attack, invading microbes, and xenobiotic induced toxicity, which would otherwise be deleterious to the preservation of fertility. The general aim of this thesis was to study these testicular defence mechanisms, including the structural building blocks of the blood– testis barrier (BTB), antimicrobial peptides, proinflammatory cytokines and ATP-binding cassette (ABC) transporter proteins. LÄS MER

  5. 19. Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)

    Författare :Henrik Viberg; Per Eriksson; Susan Schantz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; brominated flame retardants; polybrominated diphenyl ethers; PBDE; neonatal; development; neurotoxicity; behaviour; cholinergic system; Biologi; Biology; Biologi;

    Sammanfattning : This thesis examines developmental neurotoxic effects of polybrominated diphenyl ethers (PBDEs), PBDE 99, PBDE 153, and the fully brominated PBDE 209, after exposure during the newborn period in rodents. Our environment contains vast numbers of contaminants, including the flame retardants, PBDEs. LÄS MER

  7. 20. Effect of growth and development on tissue vulnerability : a study on the perinatal rat kidney

    Författare :Eva Serlachius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; development; DNA synthesis; growth; kidney; ontogeny; PKC; proximal tubular cells; pyelonephritis; rat; sodium; sodium deficiency;

    Sammanfattning : The infant is more vulnerable than older children and adults to pathological processes, such as metabolic disturbances and kidney infection. We have speculated that the vulnerability of the infant kidney may be related to the fact that the kidney at this time is undergoing rapid growth and development. LÄS MER