Sökning: "primary cortical cell cultures"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden primary cortical cell cultures.

1. 1. The effects of growth hormone on opioid-induced toxicity in vitro

   Författare :Erik Nylander; Mathias Hallberg; Alexis Bailey; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; opioids; methadone; morphine; ketobemidone; fentanyl; oxycodone; hydromorphone; insulin-like growth factor; cell viability; NG108-15; SH-SY5Y; hippocampus; cortex; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : There is an ongoing opioid crisis in the United States that is portrayed by a large number of opioid-related deaths. Many of these cases involve commonly used prescription opioids, such as morphine, oxycodone, fentanyl, and methadone. This is concerning and highlights the problems associated with long-term opioid treatment. LÄS MER

3. 2. Modulation of AMPA glutamate receptor functions in primary neuronal cultures

   Författare :Gvido Cebers; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glutamate; AMPA; cerebellar granule cells; cortical cells; cyclothiazide; AP-1; transcription factors; receptor desensitization; Ca2 ; neurotoxicity; 45Ca2 uptake; apoptosis; ischemia; muscarinic; carbachol;

   Sammanfattning : Primary neuronal cultures were used to investigate the properties of AMPA receptors and functional consequences of their activation, as well as AMPA receptor desensitization and possibilities for its modulation. We established the presence and spontaneous functional activity of AMPA receptors in cerebellar granule and cortical cell cultures. LÄS MER

4. 3. Anabolic Androgenic Steroids : Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol

   Författare :Sofia Zelleroth; Mathias Hallberg; Astrid Bjørnebekk; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anabolic androgenic steroids; testosterone; nandrolone; trenbolone; stanozolol; central nervous system; primary cortical cell cultures; rats; multivariate concentric square field; novel object recognition.; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : The use of anabolic androgenic steroids (AAS) for recreational purposes is a health concern, as long-term AAS-use in supraphysiological doses is associated with severe physical and psychological adverse effects. Several behavioral and cognitive problems are reported after long-term AAS-use, and alterations in brain morphology as well as neurotransmitter systems have been reported. LÄS MER

5. 4. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

   Författare :Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

   Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER

7. 5. Apoptotic cell death in neural stem cells exposed to toxic stimuli

   Författare :Christoffer Tamm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neural stem cells (NSCs) play an important role in the developing nervous system and in the adult brain, where mitotic regions such as the subventricular zone (SVZ) remain active. In spite of the intense ongoing research on NSCs, we still need to expand the knowledge on biochemical regulation by which NSCs undergo cell death in the course of normal physiology or in response to neurotoxic insults. LÄS MER