Sökning: "hydroxylase"

Visar resultat 6 - 10 av 160 avhandlingar innehållade ordet hydroxylase.

1. 6. Alopecia and vitiligo in autoimmune polyendocrine syndrome type I

   Författare :Håkan Hedstrand; Uppsala universitet; []
   Nyckelord :Medical sciences; APS I; autoantigen; vitiligo; alopecia areata; cDNA-library; immunoscreening; tyrosine hydroxylase; SOX9; SOX10; molecular mimicry; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Autoimmune polyendocrine syndrome type I (APS I) is a recessively inherited disease caused by mutations in a recently identified gene, AIRE, on human chromosome 21. APS I patients are affected by autoimmune destruction of multiple endocrine glands and other organs as well as ectodermal structures. LÄS MER

3. 7. GDNF gene delivery in an animal model of Parkinson's disease. Long-term effects on intact, injured and transplanted dopamine neurons using lentiviral gene transfer

   Författare :Biljana Georgievska; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; Neurology; neuropsykologi; neurofysiologi; neurophysiology; transplantation; tyrosine hydroxylase; tetracycline; striatum; substantia nigra; sprouting; regulation; neuroprotection; lentivirus; gene therapy; GDNF; behavior; dopamine; neuropsychology;

   Sammanfattning : Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to a loss of dopamine in the target structure striatum and development of motor symptoms, such as bradykinesia, rigidity and tremor. New experimental treatment strategies for Parkinson's disease are aimed at either preventing the degeneration of the dopaminergic neurons, or at restoring dopamine in the striatum by fetal dopaminergic transplants. LÄS MER

4. 8. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors

   Författare :Ayse Ulusoy; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; adeno-associated virus; dopamine; α-synuclein; tyrosine hydroxylase; RNAinterference; shRNA; substantia nigra; animal models; dyskinesia;

   Sammanfattning : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. LÄS MER

5. 9. The Role of Kidney Oxygen Homeostasis for the Development of Kidney Disease

   Författare :Carla Carvalho; Fredrik Palm; Peter Hansell; Malou Friederich; Jenny Nyström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oxygen; Kidney mitochondria; Hypoxia-inducible factors; Prolyl hydroxylase; von Hippel-Lindau; Diabetes; Aging; Kidney; Sodium; RAAS; Fysiologi; Physiology;

   Sammanfattning : The relation between oxygen supply and demand determines tissue oxygen tension (PO2). When intrarenal tissue PO2 decreases, any compensatory increase in oxygen supply via increased renal blood flow is likely to increase glomerular filtration rate. LÄS MER

7. 10. Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease

   Författare :Erik Cederfjäll; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AAV vectors; dopamine; enzyme replacement; gene regulation; GTP cyclohydrolase 1; L-DOPA; tyrosine hydroxylase; Parkinson’s disease;

   Sammanfattning : Parkinson’s disease is a brain disorder characterized by loss of dopaminergic neurons in the midbrain, resulting in the characteristic motor symptoms: resting tremor, rigidity, akinesia and postural instability. Symptomatic treatment is based on reconstituting the loss of dopamine in the brain, primarily by oral administration of its precursor L-DOPA. LÄS MER