Sökning: "Brain Repair and Imaging in Neural Systems BRAINS"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Brain Repair and Imaging in Neural Systems BRAINS.
1. Targeted gene transfer in the developing central nervous system using viral vectors
Sammanfattning : Dopamine (DA) is a neurotransmitter that plays a fundamental role in many aspects of normal brain function. The majority of DA neurons in the brain reside in one region ? the midbrain ? and project axonal connections to specific areas. One of the main target regions of the DA system is the striatum. LÄS MER
2. Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents
Sammanfattning : Motor symptoms are currently considered the first clinical hallmark of Parkinson’s disease (PD). They develop as a result of dopamine loss in the striatum, subsequent to the progressive neurodegeneration of dopamin- ergic neurons in the substantia nigra. LÄS MER
3. Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model
Sammanfattning : The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. LÄS MER
4. Statistically Guided Visualization and Exploratory Analysis of Omics Data
Sammanfattning : This thesis deals with methods for extracting robust and relevant information from high-dimensional data sets, and statistically guided visualization methods for representing the data in an informative and easily accessible way. High-dimensional data sets are becoming increasingly prevalent in many different scientific disciplines. LÄS MER
5. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors
Sammanfattning : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. LÄS MER