Sökning: "human bone marrow stromal cell"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden human bone marrow stromal cell.

  1. 1. Human Bone Marrow Microenvironment in Health and Disease

    Författare :Sandro Bräunig; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

    Sammanfattning : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. LÄS MER

  3. 2. Mesenchymal stromal cells in lung tissue

    Författare :Sara Rolandsson Enes; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenchymal stromal cells; lung transplantation; bronchiolitis obliterans syndrome; obliterative bronchiolitis; extracellular matrix;

    Sammanfattning : Mesenchymal stromal cells (MSC) are multipotent cells with immunomodulatory and regenerative properties. During recent years, the interest in using MSC for clinical approaches for various diseases have increased. LÄS MER

  4. 3. Label-free processing of stem cell preparations by acoustophoresis

    Författare :Franziska Olm; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acoustophoresis; label-free cell separation; ultrasound; microfluidics; stem cell processing; CTC separation;

    Sammanfattning : The first bone marrow transplant in a human was performed in 1959, providing evidence that cells can be used for transplantation and treatment, revealing that healing capacities lie within the human body that ought to be understood. Since then hematopoietic stem cell transplantation has developed as a standard treatment for many cancers besides other malignancies. LÄS MER

  5. 4. Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential

    Författare :Andreas Svensson; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; glioblastoma; mesenchymal stromal cell; pericyte; immunotherapy; interferon-γ;

    Sammanfattning : The most common malignant brain tumor in adults is a glioma called glioblastoma multiforme (GBM). About 300 persons are diagnosed with GBM every year in Sweden. Unfortunately, it is also the most aggressive brain tumor and as of today, it is not possible to cure it. LÄS MER

  7. 5. Laminins and Fibulins in Bone Marrow

    Författare :Yu-Chen Gu; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoids; integrin; Immunology; serology; Immunologi; serologi; transplantation; Cytology; oncology; Biokemi; Metabolism; Biochemistry; cancer; onkologi; cancerology; Cytologi; fibulin; laminin; bone marrow;

    Sammanfattning : Development of hematopoietic cells in bone marrow takes place in association with the hematopoietic microenvironment. Extracellular matrix (ECM) molecules and stromal cells in bone marrow provide a structural environment for hematopoietic cells, but they also directly influence proliferation, differentiation and migration of cells by signal transduction mediated by ligand binding to cell surface adhesion receptors. LÄS MER