Sökning: "Myeloproliferative neoplasms"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Myeloproliferative neoplasms.

  1. 1. Morbidity and childbirth in myeloproliferative neoplasms

    Författare :Anna Ravn Landtblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myeloproliferative neoplasms (MPN) are a family of chronic hematologic cancers, characterized by excess proliferation of myeloid cell lineages, or fibrosis of the bone marrow. Patients with MPN generally have a long expected survival. To elucidate morbidities during the disease course, e.g. LÄS MER

  3. 2. Clinical and epidemiological studies in myeloproliferative neoplasms

    Författare :Malin Hultcrantz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myeloproliferative neoplasms (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal hematopoietic disorders characterized by excessive terminally differentiated myeloid cells. MPNs can progress to secondary myelofibrosis or acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS). LÄS MER

  4. 3. Human Bone Marrow Microenvironment in Health and Disease

    Författare :Sandro Bräunig; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

    Sammanfattning : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. LÄS MER

  5. 4. Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms

    Författare :Helena Ågerstam; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The tyrosine kinase encoding genes ABL1 and FGFR1 are involved in fusion genes underlying the myeloproliferative neoplasms chronic myeloid leukemia (CML) and the 8p11-myeloproliferative syndrome (EMS). CML and EMS are both myeloproliferative disorders with an initiating, relatively indolent, chronic phase that after some time progresses into acute myeloid or lymphoid leukemia. LÄS MER

  7. 5. Population-Based Long-Term Follow-up of Patients with Myeloproliferative Neoplasms, complications and prognosis

    Författare :Khadija Abdulkarim; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; essential thrombocythemia; polycythemia vera; myelofibrosis;

    Sammanfattning : ABSTRACT Philadelphia chromosome negative myeloproliferative neoplasms (Ph-MPNs) are rare clonal hematological malignancies, mainly including polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). Patients with these diseases run a high risk of vascular complications and may transform to acute myeloid leukemia (AML). LÄS MER