Sökning: "housekeeping gene"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden housekeeping gene.

  1. 1. Contributions to Statistical Analysis of Gene Expression Data

    Författare :Anders Sjögren; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA microarray; differential expression; gene regulation; variance stabilising transformation; permutation; reference gene; housekeeping gene; bootstrap; quality control QC ; quality assurance QA ; quality assessment; empirical Bayes; weighted moderated t-statistic; WAME; DNA microarray;

    Sammanfattning : .... LÄS MER

  3. 2. From GWAS to gene : Zebrafish as a model system for large-scale studies of obesity and comorbidities

    Författare :Eugenia Mazzaferro; Marcel den Hoed; Randall Peterson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; genetic screens; gene editing; CRISPR Cas9; obesity; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Obesity increases the risk of developing comorbidities such as cardiovascular and metabolic diseases. However, not all obese individuals develop comorbidities, and those that do not are referred to as “metabolically healthy obesity” individuals. LÄS MER

  4. 3. Vector development for suicide gene therapy

    Författare :Alar Aints; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

    Sammanfattning : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. LÄS MER

  5. 4. New insights into the role of ppGpp and DksA through their effect on transcriptional regulation of housekeeping and colonization related genes of Escherichia coli

    Författare :Anna Åberg; Carlos Balsalobre; Anne Farewell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; type 1 fimbriae; fimB; phase variation; transcription; global gene regualtion; ppGpp; DksA; gre-factors; RNA polymerase; Medical microbiology; Medicinsk mikrobiologi;

    Sammanfattning : Bacteria have the ability to sense different environmental signals. When an environmental stress is detected, bacteria rapidly adjust their gene expression profile to be able to survive and thrive. LÄS MER

  7. 5. Transcriptional profiling of human embryonic stem cells and their functional derivatives

    Författare :Jane Synnergren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcription; differentiation; human embryonic stem cells; gene expression; Naturvetenskap;

    Sammanfattning : Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. Based on these properties, hESCs and their derivatives provide unique model systems for basic research on embryonic development. LÄS MER