Sökning: "heterocyclic"

Visar resultat 16 - 20 av 73 avhandlingar innehållade ordet heterocyclic.

  1. 16. Aromatic Allylation via Diazotization; Application in synthesis of heterocyclic compounds

    Författare :Fredrik Ek; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bengamide analogue.; parallel synthesis; trimethylsilyl azide; cycloaddition; imidazole; fused tetrazole derivatives; iodocyclization; benzazepine; tert-butyl nitrite; allylic bromide; aromatic allylation; diazotization; Organic chemistry; Organisk kemi;

    Sammanfattning : A new method for allylation of aromatic systems has been developed. A number of arylamines were converted via diazotization to the corresponding allylaromatic compounds using tert-butyl nitrite and an excess of allylic bromides with complete regioselectivity. Electron-withdrawing groups, in the aromatic moiety, were necessary to obtain good yields. LÄS MER

  2. 17. Synthesis of new building blocks for conjugated oligomers

    Författare :Fredrik Allared; KTH; []
    Nyckelord :organic semiconductors; thiophenes; heterocyclic synthesis; dithienothiophene; naphthalene;

    Sammanfattning : This thesis deals with the synthesis of new organicmaterials for electronic applications. Several new ring-formingmethods are employed to construct sulphur heterocycles: Tandemelectrophilic aromatic substitution and acid-catalyzedtransetherification of methoxythiophene, double electrophilicaromatic substitutions with ethane-1, 2-disulphenyl chloride,and also, the reaction of dienes with sulphur dichloride. LÄS MER

  3. 18. The effect on chromosomal stability of some dietary constituents

    Författare :Louise Durling; Per Eriksson; Jan Alexander; Uppsala universitet; []
    Nyckelord :Biology; Genotoxicity; chromosomal stability; heterocyclic amines; furan; HMF; folic acid; micronucleus test; comet assay; Biologi;

    Sammanfattning : When food is heated, a vast number of compounds are formed. Some of these are known to be toxic. Among these are furan, HMF, PhIP, IQ, and MeIQx, the subjects of this thesis. All these compounds are known or suspected carcinogens but the detailed mechanisms behind their carcinogenicity have not yet been fully examined. LÄS MER

  4. 19. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

    Författare :Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. LÄS MER

  5. 20. N-Heterocyclic Carbene Catalysis in Organic Synthesis - A Green Chemistry Approach

    Författare :Linda Ta; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; aerobic oxidation; ionic liquid; sustainability; NHC catalysis; oxidative NHC catalysis; green chemistry; OTHO; Organocatalysis;

    Sammanfattning : The twelve principles of green chemistry were created as a response to the multiple environmental issues caused by the release of waste from the chemical industry. The principles acts as a guide in the development of sustainable chemical processes for the syntheses of important molecules needed to sustain our living standards. LÄS MER