Sökning: "heterocyclic amines"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden heterocyclic amines.

  1. 1. Modifying Cooking Practices to Reduce the Formation of Heterocyclic Amines

    Författare :Elna Hallgard; Avdelningen för livsmedel och läkemedel; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Livsmedelsteknik; Food and drink technology; cancer; frying; mutagens; beefburger; chicken; heterocyclic amines; cooking;

    Sammanfattning : Commonly cooked meat dishes contain heterocyclic amines (HAs) at ng/g levels. HAs are animal carcinogens, form DNA adducts in human tissues, and have been associated with increased risk of cancer in epidemiological studies, and it is thus recommended that human intake be decreased. LÄS MER

  2. 2. Dietary heterocyclic amines and human cancer risk

    Författare :Katarina Augustsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cancer; colon; rectum; bladder; kidney; human; heterocyclic amines; meat;

    Sammanfattning : Heterocyclic amines formed in meat during cooking are multi-site animal carcinogens and form DNA adducts in human tissues, but their relevance to human carcinogenesis has yet to be determined. The aim of this thesis was to investigate, by epidemiological methods, whether heterocyclic amines are responsible for part of the diet-related cancer burden in humans. LÄS MER

  3. 3. Iridium Catalyzed Carbon- Heteroatom Bond Forming Reactions via Hydrogen Transfer : Method Development and Mechanistic Elucidations

    Författare :Aitor Bermejo López; Belén Martín‐Matute; Eduardo Peris; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Catalysis; N-Heterocyclic carbene; N-Alkylation; Hydrogen transfer; Amino acids; Carbohydrates; Amines; Organic Chemistry; organisk kemi;

    Sammanfattning : The present thesis describes the applicability of two different iridium(III) complexes for C-O and C-N bond forming reactions. The different projects described in this work are united by the use of an iridium catalyst bearing a functionalized N-heterocyclic carbene ligand. LÄS MER

  4. 4. The effect on chromosomal stability of some dietary constituents

    Författare :Louise Durling; Per Eriksson; Jan Alexander; Uppsala universitet; []
    Nyckelord :Biology; Genotoxicity; chromosomal stability; heterocyclic amines; furan; HMF; folic acid; micronucleus test; comet assay; Biologi;

    Sammanfattning : When food is heated, a vast number of compounds are formed. Some of these are known to be toxic. Among these are furan, HMF, PhIP, IQ, and MeIQx, the subjects of this thesis. All these compounds are known or suspected carcinogens but the detailed mechanisms behind their carcinogenicity have not yet been fully examined. LÄS MER

  5. 5. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

    Författare :Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

    Sammanfattning : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. LÄS MER