Sökning: "thermophilic enzyme"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden thermophilic enzyme.

1. 1. Enzyme Cold Adaptation through Evolution of Protein Flexibility

   Författare :Jaka Sočan; Johan Åqvist; Hugo Gutiérrez-de-Terán; Janez Mavri; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EVB; Empirical valence bond method; Pancreatic elastase; α-amylase; Enzyme catalysis; Enzyme evolution; Cold adaptation; Temperature dependence of catalytic rates; Psychrophilic enzyme; Molekylär biovetenskap; Molecular Life Sciences;

   Sammanfattning : What lives, evolves. Macromolecular catalysis is a process, central to both evolutionary and metabolic aspect of life, as it provides a systematic bias favouring certain chemical processes. LÄS MER

3. 2. Discovery and applications of family AA9 lytic polysaccharide monooxygenases

   Författare :Monika Tõlgo; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; lytic polysaccharide monooxygenases; cellulose; xylan; spruce; carbohydrate active enzymes; LPMO; lignocellulolytic enzyme cocktails; lignocellulose; polysaccharides; AA9; cellulose nanocrystals; thermophilic fungi;

   Sammanfattning : Auxililary activity family 9 lytic polysaccharide monooxygenases (abbreviated as AA9s or LPMO9s) are fungal mono-copper enzymes capable of oxidatively cleaving various plant cell wall oligo- and/or polysaccharides. LPMO9s are key components of lignocellulolytic enzyme cocktails used in today’s biorefineries to break down biomass into fermentable sugars. LÄS MER

4. 3. A study of DNA interactive proteins and their origin from thermophilic Siphoviridae phages

   Författare :Josefin Ahlqvist; Bioteknik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Thermophilic bacteriophages; Siphoviridae; Genome comparison; Protein production; DNA polymerase I; Holliday junction resolving enzyme; Structure–function relationship; Signature motifs; Bioinformatics;

   Sammanfattning : This thesis covers the results of studies on the amino acid sequence, three-dimensional structure, and activities of two types of DNA-interactive proteins: Holliday Junction resolving enzyme (represented by Hjc_15-6 isolated from phage Tth15-6) and DNA Polymerase I (represented by PolI_G20c, isolated from phage G20c), including studies on their homologous counterparts. As these proteins originate from two different, but related phages that infect Thermus thermophilus, the studies also include the evolutionary relationship between these and other related phages at genomic level. LÄS MER

5. 4. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

   Författare :Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. LÄS MER

7. 5. Transglycosylation by Glycoside Hydrolases - Production and modification of alkyl glycosides

   Författare :Pontus Lundemo; Bioteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Glycoside hydrolases; Cyclodextrin glucanotransferases; β-glucosidases; Alkyl glycosides; Thermotoga neapolitana; Organic reaction media;

   Sammanfattning : To enable the transition to a green, bio-based economy, an extensive enzymatic toolbox competitive to traditional chemical procedures is needed. One strong area for enzymes is carbohydrate chemistry, due to the over-functionalized nature of carbohydrates, difficult to handle in traditional chemistry. LÄS MER