Sökning: "unsaturated lactam"

Hittade 3 avhandlingar innehållade orden unsaturated lactam.

  1. 1. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

    Författare :Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. LÄS MER

  3. 2. Symmetry in Asymmetric Catalysis and Hydrogen Bond-Based Self-Assembly : Synthesis and Investigations

    Författare :Yutang Li; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric catalysis; bissalen; asymmetric ring opening; pseudo-Cs; hydrogen bonding; self-assembly; C3 symmety; trilactam; scXRD; solubility; epoxidation; rearrangement; Baeyer-Villiger reaction; transition state; DFT calculation; cyclodextrin; polyethylene glycol; amphiphilicity;

    Sammanfattning : The thesis elaborates on four different projects focusing on synthesizing symmetry-related molecules and investigating their performance as catalysts for asymmetric catalysis or as monomers for hydrogen bond-based self-assembly.Chapter 2 describes a new method to desymmetrize a meso-ligand. LÄS MER

  4. 3. GALIELLALACTONE ANALOGUES – SYNTHESIS AND PROPERTIES

    Författare :Ritha Gidlöf; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galiellalactone; one-pot peptide coupling and intramolecular Michael addition; tandem palladium-catalyzed carbonylation intramolecular Diels-Alder; STAT3 inhibition;

    Sammanfattning : Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. LÄS MER