Sökning: "glioblastoma"

Visar resultat 21 - 25 av 144 avhandlingar innehållade ordet glioblastoma.

1. 21. CAR T cells for Immunotherapy of Cancer

   Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

3. 22. Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis

   Författare :Katrin Svensson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; angiogenesis; hypoxia; microvesicles; exosomes; polyamines; tissue factor; coagulation;

   Sammanfattning : Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. LÄS MER

4. 23. Statistical Inference on Interacting Particle Systems

   Författare :Gustav Lindwall; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stochastic process; mathematical biology; agent based modelling; glioblastoma; Bayesian inference;

   Sammanfattning : Interacting particle systems, and more specifically stochastic dynamical systems, is a mathematical framework which allows for condensed and elegant modelling of complex phenomena undergoing both deterministic and random dynamics. This thesis is concerned with the topic of statistical inference on large systems of interacting particles, with the specific application of in vitro migration of cancer cells. LÄS MER

5. 24. Application of Genomic and Expression Arrays for Identification of new Cancer Genes

   Författare :Helena Nord; Teresita Díaz de Ståhl; Jan Dumanski; Susan Pfeifer; Blomquist Erik; Segersten Ulrika; David Gisselsson Nord; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Array-CGH; Expression array; Copy number variation; Glioblastoma; Medulloblastoma; Bladder carcinoma; Oncogenes; Tumor suppressor genes; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Medical genetics; Medicinsk genetik; Tumour biology; Tumörbiologi; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Sammanfattning : Copy number variation (CNV) comprises a recently discovered kind of variation involving deletion and duplication of DNA segments of variable size, ranging from a few hundred basepairs to several million. By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. LÄS MER

7. 25. Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation

   Författare :Ágota Tüzesi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; microRNA; DNA methylation; exosomes; glioblastoma; paediatric; glioma stem cells; neural stem cells; TMZ response;

   Sammanfattning : Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma stem cells. The generation and maintenance of these cells is orchestrated by complex genetic and epigenetic mechanisms. LÄS MER