Sökning: "gene fusion"

Visar resultat 16 - 20 av 222 avhandlingar innehållade orden gene fusion.

1. 16. Molecular Mechanisms of the DEK Protein in Leukemia

   Författare :Carl Sandén; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DEK; DEK-NUP214; fusion gene; acute myeloid leukemia; proliferation; mTOR; ChIP-seq;

   Sammanfattning : The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. LÄS MER

3. 17. Genetic dissection of tubulogenesis in the Drosophila trachea

   Författare :Johanna Hemphälä; Christos Samakovlis; Reinhard Schuh; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; trachea; transposon mutagenesis screen; fusion; Dpp; Delta; tubular dimensions; Grainyhead; Krotzkopf verkehrt; intralumenal matrix; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : The formation of branched tubular organs, such as the mammalian lung kidney and vascular system, is an essential process in animal development. The Drosophila tracheal (respiratory) system provides a genetic model system to study the highly ordered process of branch outgrowth and fusion required to form continuous tubular networks. LÄS MER

4. 18. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

   Författare :Melker Göransson; Göteborgs universitet; []
   Nyckelord :Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

   Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER

5. 19. Resolving the Genomic Complexity of Pediatric Acute Lymphoblastic Leukemia

   Författare :Yanara Marincevic-Zuniga; Ann-Christine Syvänen; Caroline Heckman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute lymphoblastic leukemia ALL ; 450k array; DNA methylation; RNA-sequencing; linked-read WGS; B-other; fusion gene; chromosomal translocation; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Structural chromosomal rearrangements are a hallmark of ALL and represent key markers for diagnosis, risk stratification and prognosis. LÄS MER

7. 20. Protein production and purification in structural genomics

   Författare :Martin Hammarström; Per-Åke Nygren; Torleif Härd; Helena Berglund; Herman van Tilbeurgh; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinational cloning; Escherichia coli; gene expression; fusion proteins; solubility; circular dichroism; nuclear magnetic resonance; Structural biochemistry; Strukturbiokemi;

   Sammanfattning : The number of gene products available for structural and functional study is increasing at an unprecedented rate as a result of the successful whole genome sequencing projects. Systematic structure determination of proteins on a genomic scale, called structural genomics, can significantly contribute to the field of protein science and to functional annotation of newly identified genes. LÄS MER