Sökning: "acute myeloid leukemia"

Visar resultat 1 - 5 av 149 avhandlingar innehållade orden acute myeloid leukemia.

  1. 1. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry

    Författare :Lovisa Vennström; Göteborgs universitet; []
    Nyckelord :Acute leukemia; population-based; incidence; survival; acute myeloid leukemia; acute lymphoblastic leukemia; acute promyelocytic leukemia; early death;

    Sammanfattning : Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. LÄS MER

  3. 2. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

    Författare :Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. LÄS MER

  4. 3. Targeting Nutrient Transporters in Acute Myeloid Leukemia

    Författare :Hannah Åbacka; Medicinsk strukturbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Akut myeloisk leukemi; Metabolism; Transportörer; GLUT1; GLUT4; CD36; AQP7; ASPL; Inhibitor; Glukos; Fettsyra; Glycerol; Acute myeloid leukemia; Metabolism; Transporter; GLUT1; GLUT4; CD36; AQP7; ASPL; Small-molecule inhibitor; Glucose; Fatty acid; Glycerol;

    Sammanfattning : .... LÄS MER

  5. 4. Targeting residual malignant cells in myeloid leukemia

    Författare :Malin Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia; chronic myeloid leukemia; histamine dihydrochloride; hydroxyurea; leukemic stem cells;

    Sammanfattning : Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated with leukemic relapse, mostly with dismal survival outcome. LÄS MER

  7. 5. Immunotherapy and immunosuppression in myeloid leukemia

    Författare :Alexander Hallner; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Natural killer cells; acute myeloid leukemia; histamine dihydrochloride; immunotherapy; reactive oxygen species; chronic myelomonocytic leukemia; NK cell education; NKG2A; HLA; KIR;

    Sammanfattning : Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. LÄS MER