Sökning: "Acute lymphoblastic leukemia ALL"

Visar resultat 1 - 5 av 73 avhandlingar innehållade orden Acute lymphoblastic leukemia ALL.

1. 1. Mechanisms of therapy resistance in acute lymphoblastic leukemia

   Författare :Kinjal Shah; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER

3. 2. Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics

   Författare :Britt-Marie Frost; Henrik Schröder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; cytotoxicity; drug resistance; pharmacokinetics; Acute lymphoblastic leukemia; childhood; in vitro assay; vincristine; doxorubicin; Down`s syndrome; CHS 828.; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

   Sammanfattning : The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. LÄS MER

4. 3. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis

   Författare :Setareh Safavi; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute lymphoblastic leukemia; hypodiploidy; adult acute lymphoblastic leukemia;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children 50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. LÄS MER

5. 4. DNA methylation as a prognostic marker i acute lymphoblastic leukemia

   Författare :Magnus Borssén; Sofie Degerman; Kim Vettenranta; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; acute lymphoblastic leukemia; T-ALL; Relapse; Telomere length; patologi; Pathology; Pediatrics; pediatrik;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. LÄS MER

7. 5. Resolving the Genomic Complexity of Pediatric Acute Lymphoblastic Leukemia

   Författare :Yanara Marincevic-Zuniga; Ann-Christine Syvänen; Caroline Heckman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute lymphoblastic leukemia ALL ; 450k array; DNA methylation; RNA-sequencing; linked-read WGS; B-other; fusion gene; chromosomal translocation; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Structural chromosomal rearrangements are a hallmark of ALL and represent key markers for diagnosis, risk stratification and prognosis. LÄS MER