Sökning: "Myxoid round cell liposarcoma"
Hittade 5 avhandlingar innehållade orden Myxoid round cell liposarcoma.
1. Molecular studies of genetic changes in myxoid and round cell liposarcoma
Sammanfattning : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. LÄS MER
2. Liposarcomas - proliferation, senescence and the role of DDIT3
Sammanfattning : Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. LÄS MER
3. Clinical and molecular studies of liposarcoma
Sammanfattning : Aims: (1) To analyse clinicopathological characteristics, treatment and outcome of liposarcoma, and to determine whether, and how, the Scandinavian Sarcoma Group (SSG) treatment guidelines were followed; (2) to analyse tumour volume and morphology response after radiotherapy in myxoid/round cell liposarcoma (MLS/RCLS); (3) to examine the role of the MLS-specific fusion gene FUS-DDIT3 in development of liposarcomas; and (4) to analyse expression patterns of cell cycle regulating proteins in MLS. Methods: (1) A total of 319 liposarcomas reported between 1986?1998 to the SSG Register were reviewed. LÄS MER
4. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3
Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER
5. FET proteins in cancer and development
Sammanfattning : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. LÄS MER