Sökning: "fusion oncogenes"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden fusion oncogenes.

  1. 1. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

    Författare :Melker Göransson; Göteborgs universitet; []
    Nyckelord :Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

    Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER

  3. 2. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

    Författare :Fredrik Persson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

    Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER

  4. 3. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors

    Författare :Anna-Karin Ström; Göteborgs universitet; []
    Nyckelord :Pleomorphic adenoma; carcinoma ex pleomorphic adenoma; lipoblastoma; PLAG1; HMGIC; chromosome translocation; promoter swapping; fusion oncogene; gene amplification;

    Sammanfattning : .... LÄS MER

  5. 4. Identification and Characterization of Novel Candidate Oncogenes

    Författare :Marina Mencinger; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk genetik; Clinical genetics; RBP56; APRIL; TFG; FUS; EWS; EST database; fusion genes; chromosome; molecular genetics; cancer; Cytology; oncology; cancerology; Cytologi; onkologi;

    Sammanfattning : Using computer-assisted sequence homology searches we identified three genes encoding proteins similar to certain fusion partner proteins in cancer. The novel APRIL gene was localized to 15q25 and encodes a protein, containing an acidic amino-acid region similar to that/those of leukemia-associated fusion partner proteins DEK and SET. LÄS MER

  7. 5. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms

    Författare :Marta Persson; Göteborgs universitet; []
    Nyckelord :cancer genetics; fusion oncogenes; chromosome translocation; MYB; NFIB; CRTC1; MAML2; salivary gland; breast; adenoid cystic carcinoma; mucoepidermoid carcinoma; hidradenoma;

    Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER