Sökning: "galectin ligand"
Visar resultat 11 - 15 av 19 avhandlingar innehållade orden galectin ligand.
11. Design and Synthesis of Galectin Inhibitors
Sammanfattning : Galectins, a lectin family, have shown binding affinities towards b-galactosides. Galectins have been proposed to be involved in a wide range of functions like for example, cell growth, adhesion, migration, chemo taxis and apoptosis. They have also been associated with various cancer types. LÄS MER
12. Design and Synthesis of Glycomimetics as Selective Galectin Inhibitors
Sammanfattning : In last couple of decades the field of glycobiology has developed rapidly due to the increased understanding of glycans’ abilities to encode biological information, which may have impact on biological event and disease, such as for example tumour growth and inflammation. This development has been accompanied by an increasing focus on drug discovery revolving around a category of carbohydrate-based drugs termed glycomimetics. LÄS MER
13. Galectin-8 specificity to cells: from broad outside to fine inside
Sammanfattning : Glycobiology is the world of sugars: how they are made, what they look like, and what they do. Despite the importance of glycan structures in life, knowledge has been hampered due to their inherent complexity. LÄS MER
14. Molecular recognition and dynamics in proteins studied by NMR
Sammanfattning : Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial protein G (PGB1). LÄS MER
15. Conformational Entropy and Protein Flexibility in Drug Design Studied by NMR Spectroscopy
Sammanfattning : Proteins are complex molecules, present in all of the vital functions of life. The function of a protein is regulated by interactions between protein and other molecules. Drug design in pharmaceutical science aims to regulate the function of a protein by the design of synthesized molecules that binds to a protein with high affinity. LÄS MER