Sökning: "macrophage elastase"

Hittade 3 avhandlingar innehållade orden macrophage elastase.

  1. 1. Conformational Entropy and Protein Flexibility in Drug Design Studied by NMR Spectroscopy

    Författare :Carl Diehl; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MMP-12; Galectin-3; confomational entropy; order parameters; ITC; Protein dynamics; isothermal titration calorimetry; macrophage elastase; nuclear magnetic resonance; NMR;

    Sammanfattning : Proteins are complex molecules, present in all of the vital functions of life. The function of a protein is regulated by interactions between protein and other molecules. Drug design in pharmaceutical science aims to regulate the function of a protein by the design of synthesized molecules that binds to a protein with high affinity. LÄS MER

  3. 2. Translational PET imaging of inflammation

    Författare :Emmi Puuvuori; Olof Eriksson; Tove Grönroos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET imaging; Nuclear Medicine; Inflammation; Translational Medicine;

    Sammanfattning : Inflammation is our body’s sophisticated defense mechanism against invading pathogens, traumas, and tumors. Repeatable and non-invasive monitoring of inflammation process would open opportunities to improve our knowledge of several diseases and enable assessment of personalized treatments. LÄS MER

  4. 3. Characterization of Pleiotropic Activities of alpha1-Antitrypsin

    Författare :Caroline Sandström; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; alpha1-Antitrypsin deficiency; alpha1-Antitrypsin;

    Sammanfattning : Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease characterized by chronic inflammatory response in the airways and lung parenchyma that involves the influx of inflammatory, structural cells and mediators. The inflammatory process resulting in lung tissue destruction, emphysema, includes the excess of uninhibited proteases released from inflammatory cells. LÄS MER