Sökning: "galectin ligand"

Visar resultat 16 - 19 av 19 avhandlingar innehållade orden galectin ligand.

1. 16. Small-Molecule Galectin Ligands : Structure-Based Optimisation of Affinity and Selectivity

   Författare :Sjors Van Klaveren; Centrum för analys och syntes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Galectins; structure activity relation;

   Sammanfattning : In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. LÄS MER

3. 17. QM/MM free-energy perturbation and other methods to estimate ligand-binding affinities

   Författare :Martin Olsson; Beräkningskemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Computer-aided drug design; protein–ligand binding; molecular dynamics; free-energy perturbation; QM MM; convergence;

   Sammanfattning : Experimental drug discovery is very time-consuming, risky and comes at a huge cost, typically several billion USD per drug. Even though decades of experimental drug discovery have provided cures of many diseases, there are still diseases for which there is no effective drug available. LÄS MER

4. 18. Bridging the gap between computational chemistry and macromolecular crystallography

   Författare :Octav Caldararu; Beräkningskemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein structure; X-ray crystallography; Neutron crystallography; Quantum mechanics; QM MM; Quantum refinement; Ensemble refinement; Water structure;

   Sammanfattning : Knowledge of the atomic structure of biomolecules, such as proteins, is paramount to understanding their function and interactions in the human body. For example, knowledge of the atomic structure of a target protein is crucial for developing drugs that bind strongly to it and thus help cure diverse diseases. LÄS MER

5. 19. Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors

   Författare :Yolanda H. Mthembu; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; O-glycans; mucins; glycosyltransferases; Helicobacter pylori; microbial adhesion;

   Sammanfattning : Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current antibiotic regimen used in the treatment to eradicate H. LÄS MER