Visar resultat 1 - 5 av 1335 avhandlingar innehållade ordet Inhibitors.
1. Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation
Sammanfattning : Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents. LÄS MER
Sammanfattning : Fermentative ethanol production from dilute-acid hydrolyzates of wood using the yeast Saccharomyces cerevisiae was investigated. Of known inhibitors in hydrolyzates, acetic acid, furfural and hydroxymethyl furfural (HMF) were found in the highest concentrations (up to about 10 g/l). LÄS MER
Sammanfattning : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. LÄS MER
4. Peptidomimetic Enzyme Inhibitors : Targeting M. tuberculosis Ribonucleotide Reductase and Hepatitis C Virus NS3 Protease
Sammanfattning : This thesis focuses on the design and synthesis of inhibitors targeting Mycobacterium tuberculosis ribonucleotide reductase (RNR) and hepatitis C virus (HCV) NS3 protease; enzymes that have been identified as potential drug targets for the treatment of tuberculosis and hepatitis C, respectively. Small peptides have been recognized as inhibitors of these enzymes. LÄS MER
Sammanfattning : Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). The C2-symmetric HIV-1 protease is one of the prime targets for chemotherapy in the treatment of the HIV infection. Inhibition of HIV-1 protease leads to immature and non-infectious viral particles. LÄS MER