Sökning: "Galectin inhibitors"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Galectin inhibitors.
1. Design and Synthesis of Galectin Inhibitors
Sammanfattning : Galectins, a lectin family, have shown binding affinities towards b-galactosides. Galectins have been proposed to be involved in a wide range of functions like for example, cell growth, adhesion, migration, chemo taxis and apoptosis. They have also been associated with various cancer types. LÄS MER
2. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications
Sammanfattning : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. LÄS MER
3. Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions
Sammanfattning : Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. LÄS MER
4. Synthetic Galectin Inhibitors Selective O-galactosyl aldoximes, multivalent lactosides and galactose-mimicking mannosides
Sammanfattning : This thesis describes the design, synthesis and evaluation of synthetic inhibitors for the carbohydrate binding proteins called galectins. Potent and selective inhibitors can be used as important research tools in the endeavor to chart the true role of galectins in biological events such as cancer and inflammation and possibly as lead for future galectin targeting drugs. LÄS MER
5. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins
Sammanfattning : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. LÄS MER
