Sökning: "galectin ligand"

Visar resultat 6 - 10 av 19 avhandlingar innehållade orden galectin ligand.

1. 6. Reading a glycocode - mechanism and function of galectin-glycan interactions

   Författare :Emma Salomonsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectin; specificity; affinity; multivalency; fluorescence anisotropy; glycan array; serum glycoproteins; anginex;

   Sammanfattning : There is an intensive interest in characterising the structure and function of galectins, which is not surprising given their many important cellular functions and strong implications in human disease. Understanding the mechanisms involved in galectin functions will help to find selective and novel strategies for disease treatment and diagnosis. LÄS MER

3. 7. Theoretical studies of protein-ligand binding

   Författare :Majda Misini Ignjatovic; Beräkningskemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-ligand binding; MD; GIST; GCMC; FEP; Solvation; Entropy; Water; QM MM-FEP; Protein-ligand binding; MD; GIST; GCMC; FEP; Solvation; Entropy; Water; QM MM-FEP;

   Sammanfattning : Understanding how drugs work is of great importance, since it can facilitate drug discovery, both time- and costwise. At the same time, it is important to have methods that can help predict how well does a potential drug molecule bind to its target. Computational methods can in many ways contribute to drug design process. LÄS MER

4. 8. Structure and energetics of molecular recognition in galectin-3-ligand interactions

   Författare :Rohit Kumar; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein-ligand interactions; molecular recognition; weak bonds; thermodynamics; enthalpy; entropy; galectin-3; carbohydrate recognition domain; x-ray crystallography; fluorescence polarization; isothermal titration calorimetry; neutron crystallography; ;

   Sammanfattning : Molecular recognition is the key aspect of any cellular and biological function. Two or more molecules interacting with each other cause the effects that drives various basic functions that are fundamental to cells. Be these protein-protein, protein-nucleic acid or protein-ligand interactions, they all play important roles in a cell. LÄS MER

5. 9. Microglial cells in Neurodegenerative Diseases. The Role of Galectin-3

   Författare :Antonio Boza Serrano; Neuroinflammation; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurosciences; microglia; Galectin-3; Alzheimer disease; Parkinson disease; innate immune system; TLR4; TREM2;

   Sammanfattning : Today, dementia such as, Alzheimer’s disease (AD), vascular diseases and motor neurodegenerative diseases, such as Parkinson’s disease (PD), represent a major public health problem. For instance, PD affect to more than 10 million people worldwide and almost 50 million people are affected by dementia. LÄS MER

7. 10. Development and applications of NMR relaxation methods to study protein and ligand dynamics

   Författare :Sven Wernersson; Biofysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear magnetic resonance; NMR; NMR relaxation; Method development; Protein dynamics; BRD4; Galectin 3; Kärnmagnetisk resonansspektroskopi; proteindynamik; Metodutveckling; NMR; BRD4; Galektin 3;

   Sammanfattning : This thesis involves the study of proteins. These molecules exist in many variants, and perform most of our bodily functions. This includes signaling (for example the presence of capsaicin, which makes food spicy), molecular transport (including oxygen), catalysis (including food digestion) and part of our body structure (such as muscles). LÄS MER