Sökning: "fibroblast growth factor"

Visar resultat 11 - 15 av 146 avhandlingar innehållade orden fibroblast growth factor.

  1. 11. The role of fibroblast growth factor 19 in human liver

    Författare :Heléne Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bile acids are synthesized in the liver and are essential for intestinal absorption of lipids. Bile acid homeostasis is crucial and if not maintained, bile acids can accumulate to toxic levels and cause severe damage to the liver. LÄS MER

  3. 12. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α : studies in two- and three dimensional in vitro models

    Författare :Anita Koskela von Sydow; Mikael Ivarsson; Torbjörn Bengtsson; Hans Törmä; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblast; Keratinocyte; TGF-β; IL-1α; coculture; fibrosis CTGF CNN 2; dermal; organotypic culture;

    Sammanfattning : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. LÄS MER

  4. 13. Posterior capsule opacification : An experimental study in vitro and in vivo

    Författare :Niklas Wallentin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Posterior capsule opacification PCO ; after-cataract; lens epithelial cell; proliferation; aqueous humor AqH ; inflammation; growth factors; basic fibroblast growth factor bFGF ; transforming growth factor-β TGF-β ; extracapsular cataract extraction; corneal incision; rabbit; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The clinical and economic significance of posterior capsule opacification (PCO) makes it an important public health problem. A better understanding of the pathogenesis in order to reduce/prevent PCO is needed. For this purpose an experimental model in the rabbit was used and further developed in thisthesis. LÄS MER

  5. 14. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis

    Författare :Tove Sandberg; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics; endothelial cell migration; angiogenesis; uPA:PAI-1 complex; uPAR; TGF-beta; PAI-1; EGF; uPA; Growth factor; gynaecology; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

    Sammanfattning : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. LÄS MER

  7. 15. Vascular endothelial growth factor receptors in angiogenesis

    Författare :Kui Huang; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; endothelial cells; VEGF receptor; signal transduction; pertide; angiogenesis; Genetik; Clinical genetics; Klinisk genetik; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Angiogenesis is a process in which new capillaries sprout from preexisting blood vessels. Vascular endothelial growth factor (VEGF) promotes endothelial cell proliferation and migration and thereby stimulates angiogenesis. VEGF receptors (VEGFRs) have been implicated as key regulatory components in endothelial cells. LÄS MER