Sökning: "Mikael Ivarsson"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Mikael Ivarsson.
1. Type I collagen synthesis in connective tissues : studies on cultured cells and tissues
Sammanfattning : .... LÄS MER
2. Tracing environmental change and human impact as recorded in sediments from coastal areas of the northwestern Baltic Proper
Sammanfattning : The eutrophication of the Baltic Sea due to increased anthropogenic nutrient loads during the 20th century is well documented and studied. However, in the Baltic Sea drainage area, humans have affected the environment longer than the environmental monitoring can provide data for. LÄS MER
3. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α : studies in two- and three dimensional in vitro models
Sammanfattning : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. LÄS MER
4. In vitro Studies of Genodermatoses Affecting Cytoskeletal Integrity and Lipid Processing in Human Epidermis : Pathogenic Mechanisms and Effects of Retinoid Therapy
Sammanfattning : Autosomal dominant epidermolytic ichthyosis (EI) is a rare disease characterized by intra-epidermal blistering due to mutations in either of two keratin genes, KRT1 and KRT10, expressed by suprabasal keratinocytes. Autosomal recessive congenital ichthyosis (ARCI) is a non-blistering, hyperkeratotic disease caused by mutations in one of the following genes: ABCA12, ALOX12B, ALOXE3, TGM1, CYP4F22, NIPAL4 and SLC27A4, which are all essential for skin barrier homeostasis. LÄS MER
5. Regulation of Fibroblast Activity by Keratinocytes
Sammanfattning : In the healing of cutaneous wounds, paracrine communication between keratinocytes and fibroblasts regulates cell differentiation, proliferation and synthesis of extracellular matrix. Deficient epidermal coverage, as seen in burn-wounds, frequently results in hypertrophic scars. LÄS MER