Sökning: "fibroblast growth factor"

Visar resultat 21 - 25 av 146 avhandlingar innehållade orden fibroblast growth factor.

  1. 21. Growth factor signaling in the breast tumor microenvironment

    Författare :Matteo Bocci; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; PDGF-C; ALK1;

    Sammanfattning : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. LÄS MER

  3. 22. Growth factor pathways in human cancer : functional and therapeutic implications

    Författare :Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

    Sammanfattning : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. LÄS MER

  4. 23. On growth factors and titanium implant integration in bone

    Författare :Victoria Franke Stenport; Göteborgs universitet; []
    Nyckelord :growth factors; signal peptides; titanium implants; osseointegration; in vivo studies;

    Sammanfattning : PurposeThe purpose of the present thesis was to investigate the bone tissue response around titanium implants with one growth factor stimulating hormone and a few different growth factor substances.Material and methodsIn four studies (study I to IV) a rabbit model were used and the growth factors i.e. LÄS MER

  5. 24. Basic fibroblast growth factor for stimulation of bone formation in osteoinductive and conductive implants

    Författare :Jian-Sheng Wang; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Biofysik; Biophysics; bone ingrowth; titanium chamber; hyaluronic acid; porous hydroxyapatite; bone graft; bFGF; demineralized bone matrix; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Basic Fibroblast Growth Factor (bFGF) is one of the endogenous factors found in bone matrix. bFGF is a mitogen for many cell types, including osteoblasts and chondrocytes. It can stimulate angiogenesis and osteoblast gene expression. LÄS MER

  7. 25. Biomolecular Aspects of Flexor Tendon Healing

    Författare :Maria Berglund; Monica Wiig; Olof Nilsson; Jan Fridén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flexor tendon healing; Growth factor; Metalloproteinase; Collagen; Proteoglycan; Myofibroblast; Hyaluronan synthase; Mast cell; Hand surgery; Handkirurgi; Orthopaedics; Ortopedi;

    Sammanfattning : Flexor tendon injuries in zone II of the hand (i.e. between the distal volar crease and the distal interphalangeal joint) can be costly for both the afflicted individual and society because of the high cost of a long rehabilitation period, complicated by tendon ruptures or scarring with adhesion formation, causing impaired range of motion. LÄS MER