Sökning: "enzyme turnover number"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden enzyme turnover number.

  1. 1. Gene therapy tools: oligonucleotides and peptides

    Författare :Jonas Eriksson; Ülo Langel; Jens Kurreck; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. LÄS MER

  3. 2. Oxidation of 1,2-Diols Using Alcohol Dehydrogenases : From Kinetic Characterization to Directed Evolution

    Författare :Cecilia Blikstad; Mikael Widersten; Stefan Lutz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzyme kinetics; alcohol dehydrogenase; directed evolution; enzyme engineering; diol; α-hydroxy aldehyde; Biokemi; Biochemistry;

    Sammanfattning : The use of enzymes as catalysts for chemical transformations has emerged as a “greener” alternative to traditional organic synthesis. An issue to solve though, is that enzymes are designed by nature to catalyze reactions in a living cell and therefore, in many cases, do not meet the requirements of a suitable biocatalyst. LÄS MER

  4. 3. Advancing systems biology of yeast through machine learning and comparative genomics

    Författare :Le Yuan; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzyme turnover number; gene essentiality; horizontal gene transfer; machine learning; deep learning; yeast species;

    Sammanfattning : Synthetic biology has played a pivotal role in accomplishing the production of high value commodities, pharmaceuticals, and bulk chemicals. Fueled by the breakthrough of synthetic biology and metabolic engineering, Saccharomyces cerevisiae and various other yeasts (such as Yarrowia lipolytica , Pichia pastoris ) have been proven to be promising microbial cell factories and are frequently used in scientific studies. LÄS MER

  5. 4. Studies on endoribonuclease RNase E and its role in RNA turnover

    Författare :Björn Sohlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene regulation RNA processing mRNA stability endoribonucleases RNase E AUUUA-motifs Archaea;

    Sammanfattning : RNA turnover is an important level of regulation of gene expression, by which a cell can rapidly adjust to changes in its environment. The turnover of RNA is done by an efficient but not well understood mechanism. LÄS MER

  7. 5. Drug use in the elderly : are quantity and quality compatible

    Författare :Inga Klarin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Population-based; cross-sectional; longitudinal; aged; aged 80 and over; drug utilization; cardiovascular agents; angiotensin-converting enzyme inhibitors; inappropriate drug use; heart failure; dementia; hospitalization; mortality; Sweden.;

    Sammanfattning : The increasing number of elderly, and the increasing drug use among the elderly, emphasizes the need to continuously monitor drug utilization in this group. The scarcity of randomized controlled trials including elderly people give population-based, observational studies an important role as source of information on drug use and drug-related problems. LÄS MER