Sökning: "dorsal root ganglia"

Visar resultat 16 - 20 av 59 avhandlingar innehållade orden dorsal root ganglia.

1. 16. Regulation of signaling molecules in sensory neurons and spinal cord : studies on nerve injury models and transgenic mice

   Författare :Tie-Jun Shi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Behaviour; cell loss; dorsal root ganglion; immunohistochemistry; in situ hybridization; mRNA; nerve injury; neuropathic pain; neuropeptides; nociception; primary sensory neuron; spinal cord.;

   Sammanfattning : Nerve injury may cause neuropathic pain in patients. Similar symptoms can also be seen in some animal models. LÄS MER

3. 17. Role of calcitonin gene-related peptide in nociception : interactions with substance P and opioids

   Författare :Long-Chuan Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Calcitonin gene-related peptide CGRP ; CGRP8-37; CGRP-like immunoreactivity; carrageenan; dorsal horn; dorsal root ganglion DRG ; experimentally-induced inflammtion ß-funaltrexamine ß-FNA ; hindpaw withdrawl latency HWL ; hot-plate test; ;

   Sammanfattning : This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. LÄS MER

4. 18. Modulation of pain by immune factors : a study on interferon-g and its receptor in nociceptive transmission

   Författare :Kristina S Vikman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cytokines; interferon-gamma; dorsal horn; hypersensitivity; nociceptive transmission; pain; GluR1; AMPA receptor; disinhibition; spontaneous activity; primary cell culture; two-compartment model; spinal cord.;

   Sammanfattning : Immune cytokines have been implicated as important neuromodulators, contributing to neuronal plasticity both in the adult and developing nervous system. In addition, they have been assigned a potential role in the generation of pathological pain, which may occur as a severe symptom following disease states in the nervous system. LÄS MER

5. 19. The effects of neurotrophic substances on primary sensory neurons following peripheral nerve injury

   Författare :Petri Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DRG; dorsal horn; NGF; BDNF; NT-3; substance P; calcitonin gene-related peptide; fluoride-resistant acid phosphatase; carbonic anhydrase; microglia; astroglia;

   Sammanfattning : Sensory impulses from the periphery is transmitted by primary sensory neurons located in dorsal root and cranial nerve ganglia. The primary sensory neurons are phenotypically diverse with regard to their expression of various chemical components. LÄS MER

7. 20. Neuropeptide circuitries regulating food and water intake

   Författare :Christian Broberger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :agouti gene-related protein; anorexia mutation; arcuate nucleus; cholecystokinin; cocaine- and amphetamine-regulated transcript; coexistence; confocal microscopy; dorsal root ganglion; feeding; hypocretin; immunohistochemistry; in situ hybridization; melanin-concentrating hormone; nodose ganglion; nucleus tractus solitaxii; orexin; paraventricular nucleus; satiety; sensory neurones; pro-opiomelanocortin; vagus nerve;

   Sammanfattning : An adequate supply of nutrients through food intake is critical for survival, as evidenced by disorders such as obesity and anorexia, which in the long run may be life-threatening. Feeding behaviour is ultimately controlled by interacting neuronal populations in the brain. LÄS MER