Sökning: "cell loss"
Visar resultat 1 - 5 av 1244 avhandlingar innehållade orden cell loss.
1. Genetic Mechanisms during Terminal Cell Fate Specification in the Drosophila CNS
Sammanfattning : Specification of the many unique neuronal subtypes found in the nervous system depends on spatiotemporal cues and terminal selector cascades, mostly acting in sequential combinatorial codes of transcription factors (TFs) to dictate cell fate. Out of 10,000 cells in the Drosophila embryonic ventral nerve cord (VNC), only 28 cells selectively express Nplp1. LÄS MER
2. Genetic pathways controlling CNS development : The role of Notch signaling in regulating daughter cell proliferation in Drosophila
Sammanfattning : The human central nervous system (CNS) displays the greatest cellular diversity of any organ system, consisting of billions of neurons, of numerous cell sub-types, interconnected in a vast network. Given this enormous complexity, decoding the genetic programs controlling the multistep process of CNS development remains a major challenge. LÄS MER
3. Genetic mechanisms regulating proliferation and cell specification in the Drosophila embryonic CNS
Sammanfattning : The central nervous system (CNS) consists of an enormous number of cells, and large cellular variance, integrated into an elaborate network. The CNS is the most complex animal organ, and therefore its establishment must be controlled by many different genetic programs. LÄS MER
4. Identification of Unique Hematopoietic Stem Cell Properties
Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER
5. Novel Insights into Haematopoietic Stem Cell Regulation and Function
Sammanfattning : The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which is used to treat many haematopoietic disorders. LÄS MER