Sökning: "GluR1"

Hittade 4 avhandlingar innehållade ordet GluR1.

  1. 1. Modulation of pain by immune factors : a study on interferon-g and its receptor in nociceptive transmission

    Författare :Kristina S Vikman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytokines; interferon-gamma; dorsal horn; hypersensitivity; nociceptive transmission; pain; GluR1; AMPA receptor; disinhibition; spontaneous activity; primary cell culture; two-compartment model; spinal cord.;

    Sammanfattning : Immune cytokines have been implicated as important neuromodulators, contributing to neuronal plasticity both in the adult and developing nervous system. In addition, they have been assigned a potential role in the generation of pathological pain, which may occur as a severe symptom following disease states in the nervous system. LÄS MER

  3. 2. The functional role of the lateral olivocochlear system and mechanisms underlying sound condtioning

    Författare :Xianzhi Niu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cochlea; dopamine; tyrosine hydroxylase; sound conditioning; apoptosis; acoustic trauma; lateral olivocochlear nucleus; D1 receptor; efferents;

    Sammanfattning : Sound conditioning is a process induced by a low-level, non-damaging acoustic stimulus that provides protection against subsequent detrimental forms of acoustic trauma. Many hypotheses have been advanced to explain the effect of sound conditioning, but the mechanisms underlying this phenomenon are still not yet known. LÄS MER

  4. 3. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Författare :Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Sammanfattning : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. LÄS MER

  5. 4. Anti-epileptic and neuroprotective mechanisms by Topiramate and Levetiracetam evaluated in primary cultures

    Författare :Mikael Ängehagen; Göteborgs universitet; []
    Nyckelord :calcium imaging; phosphorylation; kainate; glutamate; caffeine; cerebral cortex; hippocampus; field potentials; neurons; astrocytes;

    Sammanfattning : The aim of this thesis was to evaluate plausible intracellular mechanisms of action for antiepileptic drugs, Topiramate (TPM) and Levetiracetam (LEV), and to investigate if TPM possesses neuroprotective properties. The thesis is based on results from calcium imaging, immunohistochemical stainings, viability tests, and Western blot using primary cortical or hippocampal cultures, or hippocampal brain slices. LÄS MER