Sökning: "two-compartment model"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden two-compartment model.

  1. 1. Modulation of pain by immune factors : a study on interferon-g and its receptor in nociceptive transmission

    Författare :Kristina S Vikman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytokines; interferon-gamma; dorsal horn; hypersensitivity; nociceptive transmission; pain; GluR1; AMPA receptor; disinhibition; spontaneous activity; primary cell culture; two-compartment model; spinal cord.;

    Sammanfattning : Immune cytokines have been implicated as important neuromodulators, contributing to neuronal plasticity both in the adult and developing nervous system. In addition, they have been assigned a potential role in the generation of pathological pain, which may occur as a severe symptom following disease states in the nervous system. LÄS MER

  3. 2. Clinical pharmacokinetic/pharmacodynamic modelling of 5a-reductase inhibitors for the treatment of benign prostatic hyperplasia

    Författare :Per Olsson Gisleskog; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Sammanfattning : Dihydrotestosterone (DHT), a potent androgen necessary for the development of benign prostatic hyperplasia (BPH) is formed from testosterone by the enzyme 5α-reductase, of which there are two types. The irreversible 5α-reductase inhibitors dutasteride, which inhibits both isozymes, and finasteride, which inhibits only one, are intended for the treatment of BPH. LÄS MER

  4. 3. A new technique to assess dermal absorption of chemical vapor in vitro by thermogravimetric analysis (TGA)

    Författare :Matias Rauma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is a huge lack of dermal uptake data for chemicals, and it is frequent with large variations in reported permeability coefficients for chemicals with more than one data set, showing the need for a new and standardized in vitro method. The overall aim of this thesis was to develop the new method of measuring dermal absorption of chemical vapor using the TGA method. LÄS MER

  5. 4. Clinical pharmacokinetics of intravenous ethanol : relationship between the ethanol space and total body water

    Författare :Åke Norberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Introduction: Total body water (TBW) is an important parameter in pathological states where the normal regulation of fluid balance is impaired (e.g., during critical illness, congestive heart failure, bum injury and renal insufficiency). LÄS MER

  7. 5. Fluidized-Bed Reactor Systems for Chemical-Looping Combustion with Inherent Separation of CO2

    Författare :Eva Johansson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chemical-Looping Combustion; Interconnected Fluidized Beds; Carbon Dioxide Capture;

    Sammanfattning : In chemical-looping combustion (CLC) a gaseous fuel can be burnt with inherent separation of carbon dioxide. The system consists of two reactors, a fuel reactor and an air reactor and an oxygen-carrier in the form of metal oxide particles that transports oxygen from the air to the fuel. LÄS MER