Sökning: "CGRP8-37"

Hittade 5 avhandlingar innehållade ordet CGRP8-37.

1. 1. Role of calcitonin gene-related peptide in nociception : interactions with substance P and opioids

   Författare :Long-Chuan Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Calcitonin gene-related peptide CGRP ; CGRP8-37; CGRP-like immunoreactivity; carrageenan; dorsal horn; dorsal root ganglion DRG ; experimentally-induced inflammtion ß-funaltrexamine ß-FNA ; hindpaw withdrawl latency HWL ; hot-plate test; ;

   Sammanfattning : This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. LÄS MER

3. 2. Contributions of calcitonin gene-related peptide in ischemia, inflammation and nociception

   Författare :Gunilla Brodda Jansen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :5-hydroxytryptamine; acupuncture; blood flow; calcitonin gene-related pep- tide; edema formation; histamine; inflammation; ischemia; mast cells; neuropeptides; neutrophils; nociception; sensory stimulation; substance P; surgical flaps; withdrawal res;

   Sammanfattning : The sensory neuropeptide Calcitonin gene-related peptide (CGRP) is a very potent vasodilator with a wide distribution in peripheral sensory nerves, often co-stored with substance P. In the present study, the effects of CGRP in different models of ischemia, inflammation and nociception were examined. LÄS MER

4. 3. Histamine receptors and neuropeptides in the cranial circulation

   Författare :Anders Ottosson; Rättsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; Neurology; Human - arteries - CGRP - SP - mast cells; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : The sensory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) are present in human cerebral, meningeal and temporal arteries, as are peptides associated with the sympathetic (neuropeptide Y, NPY) and parasympathetic (vasoactive intestinal peptide, VIP) nervous system. NPY is a vasoconstrictor in cerebral and meningeal arteries and potentiates noradrenaline (NA) as a vasoconstrictor in temporal arteries. LÄS MER

5. 4. Contribution of the sensory nervous system : an experimental study in the rat

   Författare :Olle Löfgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :edema; hindpaw withdrawal latency HWL ; inflammation; microcirculation; scalding; sensory nervous system; sensory neuropeptide antagonists; sensory neuropeptides; thermal injury;

   Sammanfattning : The pathophysiological background to burn induced inflammatory reactions is poorly understood and present therapy options are limited. A model of thermal injury was developed to enable investigations of the acute inflammatory reactions in the periphery as well as of the transmission of nociception at the spinal cord level. LÄS MER

7. 5. Bilateral neurogenic mechanisms following acute unilateral inflammation

   Författare :Indre Bileviciute-Ljungar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bilateral changes; host defence reaction; contralateral treatment; dorsal root reflexes; cross-spinal reflexes; substance P; neurokinin A; calcitonin gene-related peptide; neuropeptide Y; nociception; inflammation; carrageenan; edema; hindpaw withdrawal latency; microdialysis; hot-plate test; Randall Selitto test;

   Sammanfattning : The contribution of neurogenic mechanisms to inflammation has been extensively studied during the last decade, but provides no clear understanding of the bilateral changes commonly seen following unilateral stimulation. This work demonstrates that bilateral neurogenic mechanisms are a part of general host defence reactions following acute unilateral challenge, for the first time revealing that local anaesthetics applied contralaterally, might be used for therapeutic purposes in relieving pain and inflammation. LÄS MER