Sökning: "Long-Chuan Yu"

Hittade 1 avhandling innehållade orden Long-Chuan Yu.

1. 1. Role of calcitonin gene-related peptide in nociception : interactions with substance P and opioids

   Författare :Long-Chuan Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Calcitonin gene-related peptide CGRP ; CGRP8-37; CGRP-like immunoreactivity; carrageenan; dorsal horn; dorsal root ganglion DRG ; experimentally-induced inflammtion ß-funaltrexamine ß-FNA ; hindpaw withdrawl latency HWL ; hot-plate test; ;

   Sammanfattning : This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. LÄS MER