Sökning: "copy number analysis"

Visar resultat 1 - 5 av 125 avhandlingar innehållade orden copy number analysis.

  1. 1. Copy Number Analysis of Cancer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Markus Mayrhofer; Anders Isaksson; Simon Tavaré; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chromosomes; oncology; bioinformatics; Bioinformatik; Bioinformatics; Oncology; Onkologi; Clinical Genetics; Klinisk genetik;

    Sammanfattning : By accurately describing cancer genomes, we may link genomic mutations to phenotypic effects and eventually treat cancer patients based on the molecular cause of their disease, rather than generalizing treatment based on cell morphology or tissue of origin.Alteration of DNA copy number is a driving mutational process in the formation and progression of cancer. LÄS MER

  2. 2. Computational Analysis of Tumour Heterogeneity

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; [2020]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. LÄS MER

  3. 3. Integrative genomic and survival analysis of breast tumors

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Szilard Nemes; Göteborgs universitet.; Gothenburg University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biostatistics; cancer; survival analysis; gemonics; DNA copy number aberrations; messenger RNA;

    Sammanfattning : With the continued accumulation of genomic data at ever increasing resolution the challenge ahead lies in reading out meaningful clinical/biological information form the data that can contribute to a better understanding of the cancerous process. The need for novel approaches, new statistical methods is therefore strong. LÄS MER

  4. 4. Interpreting the Script Image Analysis and Machine Learning for Quantitative Studies of Pre-modern Manuscripts

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Fredrik Wahlberg; Anders Brun; Lasse Mårtensson; Ewert Bengtsson; Apostolos Antonacopoulos; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; document analysis; machine learning; image analysis; digital humanities; document dating; writer identification; text recognition; Datavetenskap; Computer Science;

    Sammanfattning : The humanities have for a long time been a collection of fields that have not gained from the advancements in computational power, as predicted by Moore´s law.  Fields like medicine, biology, physics, chemistry, geology and economics have all developed quantitative tools that take advantage of the exponential increase of processing power over time. LÄS MER

  5. 5. Genomic profiling of breast cancer by microarray-based technology and bioinformatics

    Detta är en avhandling från Department of Oncology, Clinical Sciences, Lund University

    Författare :Johan Staaf; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Survival; Prognostic predictor; Gene Expression; ERBB2; HER2; Microarray; Copy Number Analysis; CGH; aCGH; Amplification; Gene expression analysis;

    Sammanfattning : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. LÄS MER