Sökning: "fusion transcript detection"

Hittade 3 avhandlingar innehållade orden fusion transcript detection.

  1. 1. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects

    Författare :Gunnar Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ewing s sarcoma; synovial sarcoma; translocation; fusion gene; fusion protein; diagnosis and prognosis;

    Sammanfattning : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. LÄS MER

  3. 2. Computational Analysis of Tumour Heterogeneity

    Författare :Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. LÄS MER

  4. 3. Prognostic molecular markers of childhood leukemia

    Författare :Fredrika Gauffin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute lymphoblastic leukemia; dic 9; 20 ; dried blood spots; Guthrie card; RNA; PTEN; SHP1; VEGF; VEGFR-1; VEGFR-2; immuhistochemistry; tissue micro array;

    Sammanfattning : During the last decades there has been a dramatic increase in survival rates for childhood leukemia, resulting today in an overall survival close to 90 % for children with acute lymphoblastic leukemia (ALL). This accomplishment is largely due to treatment protocols based on careful risk group assessment guiding the type and intensity of the anti-leukemic treatment. LÄS MER