Sökning: "human genome and gene expression analyses"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden human genome and gene expression analyses.

1. 1. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome

   Författare :Husen Muhammad Umer; Jan Komorowski; Claes Wadelius; Jan Korbel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

   Sammanfattning : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. LÄS MER

3. 2. Gene Expression Profiling of Human Atherosclerosis

   Författare :Sara Hägg; Linköpings universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

   Sammanfattning : Atherosclerosis is the main underlying cause of coronary artery disease (CAD) and stroke. These two diseases are leading causes of death in the developed world. The socio-economical cost for treatments and absence of work is enormous. Recent numbers from the US show no tendency of decline in the spread of atherosclerosis. LÄS MER

4. 3. Genes predisposing to type 2 diabetes and cardiovascular mortality

   Författare :Jenny Fredriksson; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; APM1; PPARG; PPARGC1A; survival abalysis; Medicin människa och djur ; Medicine human and vertebrates ; Type 2 Diabetes; cardiovascular mortality; glycogen synthase; adiponectin; GYS1;

   Sammanfattning : Cardiovascular complications are frequent in type 2 diabetes (T2D) and cardiovascular death is the most common cause of death for these individuals. A region on chromosome 19 (19q13) has been indicated by several genome scans as a susceptibility locus for T2D or components of the metabolic syndrome (MetS). LÄS MER

5. 4. Expression and Mutation Analyses of Candidate Cancer Genes In Situ

   Författare :Sara Kiflemariam; Tobias Sjöblom; Fredrik Pontén; Mef Nilbert; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; in situ; in situ hybridization; padlock probes; mRNA; tyrosine kinases; tyrosine phosphatases; fusion transcripts;

   Sammanfattning : Cancers display heterogeneity in genetic profiles of the individual cancer cells and in the composition of different malignant and non-malignant cell populations. Such intra-tumor heterogeneity plays a role in treatment response and the emergence of resistance to cancer therapies. LÄS MER

7. 5. Candidate gene analyses and genome-wide screens in multiple sclerosis

   Författare :Vilmantas Giedraitis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. LÄS MER