Sökning: "Erik Sonnhammer"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Erik Sonnhammer.

1. 1. From networks to pathway analysis

   Författare :Miguel Castresana Aguirre; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Biological mechanisms stem from complex intracellular interactions spanning across different levels of regulation. Mapping these interactions is fundamental for the understanding of all types of biological conditions, including complex diseases. Each experimental approach carries its own bias and noise. LÄS MER

3. 2. The relationship between orthology, protein domain architecture and protein function

   Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER

4. 3. Computational Analysis of Tumour Heterogeneity

   Författare :Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. LÄS MER

5. 4. Network and gene expression analyses for understanding protein function

   Författare :Oliver Frings; Erik Sonnhammer; Rune Linding; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; network inference; network analysis; clustering; network module; network crosstalk; expression analysis; gene signature; biomarker; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Biological function is the result of a complex network of functional associations between genes or their products. Modeling the dynamics underlying biological networks is one of the big challenges in bioinformatics. LÄS MER

7. 5. Functional association networks for disease gene prediction

   Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER