Sökning: "pathway annotation"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden pathway annotation.

1. 1. Global functional association network inference and crosstalk analysis for pathway annotation

   Författare :Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. LÄS MER

3. 2. Probalistic Methods In Genomic Data Analysis

   Författare :Thomas Breslin; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pathway profiling; Bioinformatics; medical informatics; biomathematics biometrics; Bioinformatik; medicinsk informatik; differential gene expression; probabilistic methods; Natural science; Naturvetenskap; biomatematik; annotation analysis; microarray; Fysicumarkivet A:2004:Breslin;

   Sammanfattning : In this thesis, three aspects of gene expression data analysis are discussed: Differential gene expression is addressed by a probabilistic method. Gene annotation enrichment analysis is discussed in the context of multiple hypothesis testing and the choice of null hypothesis. LÄS MER

4. 3. Computational Analysis of Tumour Heterogeneity

   Författare :Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. LÄS MER

5. 4. Functional association networks for disease gene prediction

   Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER

7. 5. Computational and comparative investigations of syntrophic acetate-oxidising bacteria (SAOB) : genome-guided analysis of metabolic capacities and energy conserving systems

   Författare :Shahid Manzoor; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Today's main energy sources are the fossil fuels petroleum, coal and natural gas, which are depleting rapidly and are major contributors to global warming. Methane is produced during anaerobic biodegradation of wastes and residues and can serve as an alternative energy source with reduced greenhouse gas emissions. LÄS MER