Sökning: "cisplatin treatment"

Visar resultat 6 - 10 av 87 avhandlingar innehållade orden cisplatin treatment.

  1. 6. Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects

    Författare :Marie-Louise Fjällskog; Morten Vatn; Uppsala universitet; []
    Nyckelord :Medical sciences; pancreatic tumors; somatostatin analogs; cisplatin; etoposide; somatostatin receptors; immunohistochemistry; tyrosine kinase receptors; platelet-derived growth factors receptors PDGFRs ; c-kit; epidermal growth factor receptor EGFR ; MEDICIN OCH VÅRD; alfa-interferon; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : We treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs. LÄS MER

  3. 7. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men

    Författare :Anders Johnsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; cancerology; oncology; Cytology; immunohistochemistry; nephrotoxicity; pharmacodynamics; pharmacokinetics; Cisplatin; DNA adducts; platinum; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. LÄS MER

  4. 8. Cisplatin : a platinum-containing antineoplastic drug : perspectives on analytical chemistry and prevention of ototoxicity

    Författare :Pernilla Videhult Pierre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cisplatin;

    Sammanfattning : The platinum-containing drug cisplatin plays a key role in the curative and palliative treatment of many solid malignancies. Unfortunately, the treatment can lead to sensorineural hearing loss, which limits the use of the drug. LÄS MER

  5. 9. Treatment of Head and Neck Cancer, Effects on Health-Related Quality of Life and Nutrition

    Författare :Malin Berg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; HRQOL; treatment; cancer-related fatigue; elderly; nutrition;

    Sammanfattning : The aim of this thesis was to explore the impact of treatment on health-related quality of life (HRQoL), fatigue and nutrition in head and neck cancer (HNC) patients. The tumour locations often induce problems with swallowing and nutrition. LÄS MER

  7. 10. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance

    Författare :Andreas Tyler; Kjell Grankvist; Simon Ekman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin resistance; exosomes; gb3; HSP70; the Bcl-2 family; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi; onkologi; Oncology;

    Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER