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Visar resultat 1 - 5 av 166 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. The role of angiomotin in endothelial cell motility and cell-cell junction formation

    Författare :Anders Bratt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; cancer; angiostatin; angiomotin; cell motility cell-cell junction; tight junction; adherens junction;

    Sammanfattning : Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design novel therapies against cancer. LÄS MER

  3. 2. Role of Cell-cell Interactions and Palmitate on β-cells Function

    Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER

  4. 3. Macrophage-material surface interactions

    Författare :Christina Gretzer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; biomaterials; cell-cell interactions; cell-material interactions; cytokines; differentiation; fibrinogen; hydrogen peroxide; LPS; monocytes; particles;

    Sammanfattning : Material surface-stimulated activation of the macrophage and the release of mediators has been suggested to be an important factor for inflammation and tissue regeneration around biomedical implants. Macrophage interactions with particles released from implants as well as macophage-bacteria interactions are also involved in implant loosening processes. LÄS MER

  5. 4. Live Single Cell Imaging and Analysis Using Microfluidic Devices

    Författare :Mohammad Ali Khorshidi; Helene Andersson-Svahn; Håkan Jönsson; Carolina Wählby; Johan Elf; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single cell analysis; time-lapse fluorescence imaging; automated image analysis; microwell; droplet microfluidics; NK cells; single cell tracking; migration behavior analysis; cell-cell interaction; optical microscopy; image analysis; image processing; microfluidics; immune cells; tracking; counting; morphology analysis;

    Sammanfattning : Today many cell biological techniques study large cell populations where an average estimate of individual cells’ behavior is observed. On the other hand, single cell analysis is required for studying functional heterogeneities between cells within populations. LÄS MER

  7. 5. Effects of galectins and antibodies in HIV infection; Novel Assays

    Författare :Enas Sheik-Khalil; Institutionen för laboratoriemedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; galectin-1; galectin-8; neutralizing antibodies; cell-cell fusion; Microscale anisotropy assay; virus binding assay; glycosylation; gp120; Automated plaque reduction assay; CellProfiler; NeutNet;

    Sammanfattning : The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. LÄS MER