Sökning: "Gunilla Westermark"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Gunilla Westermark.

1. 1. Role of Cell-cell Interactions and Palmitate on β-cells Function

   Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER

3. 2. Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models

   Författare :Xiaohong Gu; Gunilla Westermark; Anders Olofsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; ATTR; ATTR amyloidosis; crystalline structure; aggrephagy; Drosophila melanogaster; Gal4-UAS; electron tomography; DAMS; SOHA; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). LÄS MER

4. 3. Kinetic stabilization of transthyretin and its role as an inhibitor of Aβ amyloid formation

   Författare :Lina Nilsson; Anders Olofsson; Elisabeth Sauer-Eriksson; Gunilla Westermark; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amyloid; transthyretin; amyloid beta; kinetic stabilizer; biokemi; Biochemistry;

   Sammanfattning : Amyloid formation occurs when normally soluble proteins and peptides misfold and aggregate into intractable threadlike structures called fibrils. There are currently more than 30 proteins associated with this aberrant structure, including the Aβ peptide in Alzheimer’s disease (AD) and transthyretin (TTR) in TTR amyloidosis. LÄS MER

5. 4. Deposition and Resolution of AA Amyloid

   Författare :Sofia N. Nyström; Gunilla T Westermark; Christoph Röcken; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AA-amyloid; autophagy; resolution; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi;

   Sammanfattning : Amyloidosis is a group of protein misfolding diseases characterized by extracellulardeposition of fibrillar protein aggregates. Today more than 25 different human amyloidogenicproteins have been identified, causing a variety of pathological conditions that includeAlzheimer’s disease, type 2 diabetes and prion diseases. LÄS MER

7. 5. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease

   Författare :Marie Oskarsson; Gunilla Westermark; Mikael Oliveberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; type 2 diabetes; Alzheimer disease; BRICHOS; heparan sulfate; islet amyloid; amyloid plaques; seeding; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. LÄS MER