Sökning: "galectin-8"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet galectin-8.
1. Effects of galectins and antibodies in HIV infection; Novel Assays
Sammanfattning : The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. LÄS MER
2. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins
Sammanfattning : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. LÄS MER
3. Galectin-8 specificity to cells: from broad outside to fine inside
Sammanfattning : Glycobiology is the world of sugars: how they are made, what they look like, and what they do. Despite the importance of glycan structures in life, knowledge has been hampered due to their inherent complexity. LÄS MER
4. Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Sammanfattning : Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. LÄS MER
5. Small-Molecule Galectin Ligands : Structure-Based Optimisation of Affinity and Selectivity
Sammanfattning : In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. LÄS MER