Sökning: "angiomotin"
Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet angiomotin.
1. Controlling angiogenesis : functional studies of angiomotin
Sammanfattning : The expansion of a blood circulatory network by the process of angiogenesis is essential for embryonic as well as postnatal growth. Deregulated blood vessel formation may also negatively contribute to the pathogenesis of diseases, e.g. cancer and diabetic retinopathy. LÄS MER
2. The role of angiomotin in angiogenesis
Sammanfattning : Angiogenesis plays key roles during embryonic development, female reproduction and wound repair. Angiogenesis, the formation of new blood vessels from of pre-existing capillaries, is a process tightly regulated by a balance between positive and negative regulators. LÄS MER
3. The role of angiomotin in endothelial cell motility and cell-cell junction formation
Sammanfattning : Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design novel therapies against cancer. LÄS MER
4. Making endothelial cells move : a study of angiomotin and binding partners
Sammanfattning : Angiogenesis is a process crucial for tumor growth and metastasis formation and encompasses the control of endothelial directional migration, anastomosis and lumen formation. We have previously shown that Angiomotin (Amot), a membrane-associated scaffold protein, plays an essential role in controlling endothelial cell migration and cellshape. LÄS MER
5. Exploring signaling pathways in endothelial mechanotransduction
Sammanfattning : Mechanotransduction, the process by which cells sense and convert mechanical forces from their surroundings, plays a pivotal role in cellular function. For vascular endothelial cells, coping with the continuous and significant shear stress caused by blood flow is essential for the stability of the circulatory system. LÄS MER
