Sökning: "bone cell adhesion"
Visar resultat 1 - 5 av 48 avhandlingar innehållade orden bone cell adhesion.
1. Consequences of Shb Deficiency on Hematopoietic Cell Function
Sammanfattning : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. LÄS MER
2. Interactions between whole blood and TiO₂ surfaces with focus on adhesion and activation of PMN granulocytes
Sammanfattning : Foreign materials come in contact with the human body more and more frequently. The surgical procedure of inserting an implant into the body will cause bleeding, evoke an inflammatory response and initiate a healing process, ultimately leading to acceptance or rejection of the material. LÄS MER
3. A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies
Sammanfattning : The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, were inserted in the rat tibia, or incubated in mono- or co-culture of human monocytes and MSCs. LÄS MER
4. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders
Sammanfattning : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. LÄS MER
5. Deregulation and editing of microRNAs in metastatic prostate cancer
Sammanfattning : Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. LÄS MER